TIM29 is required for enhanced stem cell activity during regeneration in the flatworm Macrostomum lignano
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چکیده
منابع مشابه
The Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano.
The Hippo pathway orchestrates activity of stem cells during development and tissue regeneration and is crucial for controlling organ size. However, roles of the Hippo pathway in highly regenerative organisms, such as flatworms, are unknown. Here we show that knockdown of the Hippo pathway core genes in the flatworm Macrostomum lignano affects tissue homeostasis and causes formation of outgrowt...
متن کاملGenome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.
The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts. This set of unique properties makes many flatworms attractive organisms for studying the evolution of pathways involved in tissue self-renewal, cell-fate spec...
متن کاملThe Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research
Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH, cell volume, and membrane potentials. Together with ion transporters and gap junction complexes,...
متن کاملA platform for efficient transgenesis in Macrostomum lignano, a flatworm model organism for stem cell research
1 European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV, Groningen, The Netherlands. 2 Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands. 3 Institute of Cytology and Genetics, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia. 4 Institute o...
متن کاملDual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.
PIWI proteins and piRNA pathways are essential for transposon silencing and some aspects of gene regulation during animal germline development. In contrast to most animal species, some flatworms also express PIWIs and piRNAs in somatic stem cells, where they are required for tissue renewal and regeneration. Here, we have identified and characterized piRNAs and PIWI proteins in the emerging mode...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-020-80682-7